Anti-inflamm proteins may contribute to chronic pain

Chronic widespread pain, a common medical condition, can be difficult to treat and is often associated with fatigue, poor sleep and depression.

A connection between fibromayalgia (FM) and cytokines (proteins that act as messengers between cells) was suspected after cancer patients treated with the cytokine interleukin -2 developed FM-like symptoms. Since then, other studies have shown contra…

New hope for tissue regeneration and joint repair

Recent study indicates therapeutic promise of adult human multi-potent Stem Cells derived from the thick membrane covering the surface of bones.

Inflammation, cartilage and bone erosions, joint destruction that’s the typical progression of arthritis and most rheumatic diseases.

While inflammation may be controlled, and perhaps even eliminated, with early aggressive treatment, few therapeu…

Stem cells from muscles can repair cartilage

Study Finds Genetically Engineered Muscle-Derived Stem Cells Improved Cartilage Repair in Rats.

Damage to articular cartilage (cartilage covering the ends of bones where they meet in a joint) frequently occurs due to injury or illness, and can lead to degenerative disease.

Treatments and experimental approaches to repair this articular cartilage have achieved limited results, but currentl…

New evidence for achieving remission of early rheumatoid arthritis

A 2-Year Study of Patients with early, aggressive disease demonstrates significantly superior results of Anti-TNF (tumor necrosis factor) plus DMARD (disease modifying anti-rheumatic drug) therapy over either therapy alone.

A chronic and potentially crippling inflammatory disorder, rheumatoid arthritis (RA) progressively wears away the cartilage and bone. Joint erosions are routinely seen wi…

Nature suggests a promising strategy for artificial bone

Researchers report they have harnessed the unique physics of sea water as it freezes to guide the production of what could be a new generation of more biocompatible materials for artificial bone that may be suitable for replacement hips, knees and a variety of dental materials.

As published in the journal Science, the researchers used this novel technique to produce a thinly layered composit…

Neuroscientists regenerate severed spinal cord

Research by scientists at King’s College London may pave the way for new treatments of spinal cord injuries. Spinal cord injuries typically arise from car accidents, violence, falls and sports injuries, with an average of two new cases admitted every day in the UK alone.

In research published in Nature* this week, scientists from the Centre for Neuroscience Research at King’s, show how an en…

Exercise response varies with genetics

Study Identifies Genes and Mutations Associated with Exercise Traits.

Your parents may be to thank(or to blame) for how your body responds to exercise, and the genes responsible are slowly being identified. That’s one of the conclusions of research published by the American College of Sports Medicine (ACSM.) As presented in the November issue of ACSM’s official journal, Medicine & Scienc…

High-dose vitamin D Prevents Fractures In Elderly

A new analysis of nearly a dozen studies testing vitamin D in older individuals has concluded that it takes a daily dose of at least 800 international units (IU) to consistently prevent broken bones.

A dose that high was found to reduce the risk of hip fracture by 30 percent and other breaks by 14 percent. Lower doses didn’t have any effect.

The report, published in the New England Journa…

Animal studies show promise treating severe chronic pain

In the current issue of the Journal of Clinical Investigation, a team of scientists established in a series of animal studies the therapeutic potential of selectively deleting specific nerve cells from the nervous system that convey severe chronic pain.

So effective was the treatment in eight dogs severely affected by osteroarthritis, cancer-related pain, or both, all eventually became more …

Discovery of crocs temperature regulator may lead to major pain relief

Sydney University researchers have identified how crocodiles and other reptiles detect temperature – shedding new light on their adaptation to environmental changes and pointing to new pain treatments for humans.

Dr Frank Seebacher and Dr Shauna A Murray from Sydney University’s School of Biological Sciences have shown that reptiles possess a family of genes that code for proteins which act …